IV infusion Initially 5 mg/kg over 20 min to 2 hr repeated 2 or 3 times/24 hr. Maintenance: 10-20 mg/kg/day or 600-800 mg/24 hr up to 1.2 g/24 hr in 250 mL of glucose soln.
Contraindications
Sinus bradycardia, sinus arrest & SA block w/o prosthesis, hypersensitivity to iodine, circulatory collapse, severe hypotension. Pregnancy & lactation. Childn <3 yr due to presence of benzyl alcohol.
Special Precautions
Exclusively administer as infusion. Avoid very slow inj. Electrolyte disturbances particularly hypokalemia. Regularly monitor liver function, ECG & BP. Long-term treatment in concomitant w/ general anesth.
Adverse Reactions
Local inflammatory reaction eg, superficial phlebitis; hot flushes, sweating, nausea, hair loss; moderate & transient decrease in BP, bradycardia; moderate & isolated elevation in transaminases; acute resp distress associated w/ interstitial pneumonitis.
Drugs liable to induce Torsade de pointes: Class IA & III antiarrhythmics, sultopride, bepridil, cisapride, diphemanil, erythromycin, mizolastine, sparfloxacin, vincamine; diltiazem, halofantrine, pentamidine, moxifloxacin, certain neuroleptics, β-blockers other than sotalol & esmolol.
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